Focus groups are a useful strategy in qualitative health research when it is important to understand how social contexts shape participants’ health. However, when cross-lingual focus groups are conducted, and in languages in which the researcher is not fluent, it raises questions regarding the usefulness and rigor of the findings. In this article, we will discuss three different approaches to cross-lingual focus groups used in a community-based participatory research project with pregnant and postpartum, African immigrant women in Alberta, Canada. In two approaches, we moderated focus groups in women’s mother tongue with the support of real-time interpreters, but in the first approach, audio recording was used and in the second approach, audio recording was not used. In the third approach, a bilingual moderator facilitated focus groups in women’s mother tongue, with transcription and translation of audio-recorded data upon completion of data generation. We expect the lessons learned in this project may assist others in planning and implementing cross-lingual focus groups, especially in the context of community-based participatory research.