A conceptual model was designed and tested to predict immigrant children’s oral health in Canada by examining parental acculturation and perceived social support (PSS) using structural equation modelling. A convenience sample of first-generation immigrant parents and their children aged 2–12 years were recruited by multilingual community workers in Edmonton, AB, Canada. Parents completed a validated questionnaire on demographics, child’s oral health (OH) behaviours, parental acculturation and PSS. Dental examinations determined children’s dental caries rate using DMFT/dmft index. Structural equation modelling (SEM) was used to analyse the data. A total of 336 families participated in this study. The findings emphasize the important role of parental acculturation and PSS levels in predicting immigrant children’s oral health behaviours and dental caries.